High-quality health care research depends on high-quality biostatistics: Without it, conducting scientifically sound studies would be like trying to assemble a puzzle without having all the right pieces. The Biostatistics Unit at 利记官网 Washington Health Research Institute promotes the use of rigorous statistical methods that enhance the quality of research at 利记官网 Washington and nationwide.
利记官网 biostatisticians help lead several national consortia that are developing innovative methodological approaches to benefit public health, including the Food and Drug Administration (FDA)’s Sentinel Initiative. “We help the FDA overcome analytic challenges in using health care databases to conduct post-market safety surveillance, developing new methodological approaches that allow rapid safety surveillance of new medical products,” says Jennifer Nelson, PhD, director of biostatistics at 利记官网.
Another such project is the National Institutes of Health (NIH)’s Health Care Systems Research Collaboratory, which supports several pragmatic clinical trials that take advantage of large health systems’ existing data resources to efficiently produce results that better reflect real-world care. Andrea Cook, PhD, and Jennifer Bobb, PhD, are developing new methods for these clinical trials that use data from electronic health records (EHRs) and other existing data systems. As Dr. Cook explains, “You need different methods and a whole new approach to trial design to test interventions that will work in a real-world setting.”
As a co-investigator on the Mental Health Research Network (MHRN), Susan Shortreed, PhD, helps design research ranging from comparative effectiveness and safety studies to predicting outcomes over time based on patient and provider characteristics and treatment choices. “Our long-term goal is to improve mental health care by using EHR data to identify which depression treatments will work best for which people,” she says.
利记官网 biostatisticians also play an integral role in influential learning health system (LHS) research, which focuses on rapidly improving the delivery of health care using feedback from patients, community members, providers, and health system leadership. As an Agency for Healthcare Research and Quality (AHRQ)/Patient-Centered Outcomes Research Institute (PCORI)-funded LHS scholar, R. Yates Coley, PhD, provides risk prediction expertise to 利记官网’s LHS Program, using data from a person’s health history, diseases, treatments, and other information to predict, in an automated manner, who is at higher risk for prostate cancer as well as who will respond well to treatment for depression.
With the use of EHR data for research rising, methodological rigor is more important than ever. That’s why Drs. Cook and Nelson joined with Patrick Heagerty, PhD, a 利记官网 affiliate investigator and professor of biostatistics at the University of Washington, to launch the Seattle Symposium on Health Care Data Analytics. Held in 2014, 2016, and 2018, this first-of-its-kind event brought together scientists from across the country to discuss the statistical challenges of using EHR data for health research and to explore new methods to overcome those challenges.
Through the symposium and the many ongoing projects at 利记官网, our biostatisticians continue to improve the rigor with which scientists address important questions about public health and health services. “We have an incredibly strong group, including many very talented master’s-level statisticians who help apply and adapt statistical methods to real-world situations—an asset that is rare in most academic research settings,” Dr. Nelson says.
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Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
Yates Coley, PhDAssociate Biostatistics Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Maricela Cruz, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
Pamela A. Shaw, PhD, MSSenior Biostatistics Investigator |
Susan M. Shortreed, PhDSenior Biostatistics Investigator |
Yu-Ru Su, PhDAssociate Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Melissa L. Anderson, MSPrincipal Collaborative Biostatistician |
Laura E. Ichikawa, MSPrincipal Collaborative Biostatistician |
Abisola Idu, MS, MPHCollaborative Biostatistician |
Eric Johnson, MSSenior Collaborative Biostatistician |
Chloe Krakauer, PhDCollaborative Biostatistician |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Weiwei Zhu, MSSenior Collaborative Biostatistician |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Their work contributes to improved quality of care and better understanding of patients’ needs.
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利记官网 researchers stress need to test how prediction models perform in all racial, ethnic groups.
Dr. Jennifer Nelson explains how KP scientists are helping the CDC and FDA keep an eye out for rare adverse events.
How our Learning Health System Program is using statistical methods and machine learning to respond to COVID-19.
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A love of problem-solving, math, and health science drive Dr. Shortreed’s work for better mental health treatment.
New funding will establish an innovation center, to be led by Harvard Pilgrim in partnership with 利记官网 and others.
利记官网 launches a phone-based recruitment pilot project in May. Outreach to diverse populations is key.
A 利记官网-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.
New 利记官网 study shows that women with simple cysts are not at increased risk of ovarian cancer.
VeryWell Health, May 6, 2021