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Vaccines & Infectious Diseases

“To combat infectious diseases, such as COVID-19 and influenza, 我们正在全面评估目前使用的疫苗的安全性和有效性, conducting clinical trials of promising new vaccines, and studying the patterns of how these illnesses spread.”

Lisa A. Jackson, MD, MPH
凯撒永久华盛顿健康利记官网所高级利记官网

Research overview

疫苗通过保护人们免受传染病——脊髓灰质炎——的侵害来挽救生命, influenza, and pneumonia to name a few. 凯撒永久医疗机构华盛顿健康利记官网所(利记官网 Washington Health Research Institute, 利记官网)正在努力通过不断提高对公共卫生具有重要意义的传染病疫苗的安全性和有效性的利记官网来保护社区.

这项工作的核心是测试针对COVID-19等新出现疾病的新疫苗. In March 2020, 利记官网 gave the world’s first-ever injection 在高级利记官网员的领导下,一种新型冠状病毒疫苗正在进行1期临床试验 Lisa A. Jackson, MD, MPH. 我们将继续站在了解和抗击COVID-19的最前沿. To learn more, see COVID-19 research at 利记官网.

利记官网所30多年来疫苗利记官网取得的成就包括:

  • 一项针对老年人接种流感疫苗的大型利记官网发现,疫苗可能无法像希望的那样保护他们免受肺炎的侵害
  • 对全国老年人带状疱疹疫苗安全性的“实时”评估 Vaccine Safety Datalink network
  • 利记官网性流感疫苗的临床试验,包括针对大流行性流感和流感的疫苗 bird flu, in adults
  • Studies to better understand and address vaccine hesitancy 在那些因为担心安全而推迟或拒绝给孩子接种疫苗的家庭中, 导致百日咳和麻疹等潜在致命疾病的爆发
  • 成人肺炎球菌多糖疫苗有效性的最大回顾性利记官网, 也是该疫苗安全性的最大临床试验
  • The pivotal clinical trials of 7-valent, 13-valent, 老年人使用20价肺炎球菌结合疫苗 

我们目前关于疫苗和传染病的利记官网项目包括:

  • 疫苗和治疗评价股进行的临床试验, 由国家过敏和传染病利记官网所资助, 也是传染病临床利记官网联盟(IDCRC)的成员. Led by Dr. Lisa Jackson, the unit launched the world’s first trial of an experimental COVID-19 vaccine — the now-approved NIH-Moderna vaccine ——并继续测试COVID-19疫苗和增强剂的安全性和有效性. To learn more, see COVID-19 research at 利记官网.
  • 利记官网COVID-19和流感等传染病如何在社区传播
  • 开展利记官网,探索哪种类型的沟通和社区参与战略最有效地提高长期护理机构工作人员的COVID-19疫苗吸收率. Clarissa Hsu, PhD他领导了这项利记官网,该利记官网由美国联邦政府资助.由以患者为中心的结果利记官网所(PCORI).
  • 美国正在对流感和COVID-19疫苗的有效性进行持续监测.S. Influenza Vaccine Effectiveness Network, led by Karen J. Wernli, PhD, 利记官网高级利记官网员,由疾病控制和预防中心资助。
  • Studies of immunization safety through the Vaccine Safety Datalink project, 由疾病预防控制中心支持,并将包括华盛顿凯撒医疗机构在内的8个美国健康计划维护的大型数据库中的信息连接起来
  • Methodological research, led by Jennifer C Nelson, PhD, and Andrea J. Cook, PhD, 改进用于解决电子健康记录数据设置中疫苗安全问题的统计设计和分析方法

Recent publications on Vaccines & Infectious Disease

Branche AR, Rouphael NG, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Anderson EJ, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub +++. 二价和单价SARS-CoV-2变异疫苗的比较:2期随机开放标签COVAIL试验. Nat Med. 2023;29(9):2334-2346. doi: 10.1038/s41591-023-02503-4. Epub 2023 Aug 28. PubMed

Irving SA, Crane B, Weintraub E, Kauffman TL, Brooks N, Patel SA, Razzaghi H, Belongia EA, Daley MF, Getahun D, Glenn SC, Hambidge SJ, Jackson LA, Kharbanda E, Klein NP, Zerbo O, Naleway AL. 2019冠状病毒病(COVID-19)大流行之前和期间孕妇接种流感疫苗. Obstet Gynecol. 2023 Sep 1;142(3):636-639. doi: 10.1097/AOG.0000000000005285. Epub 2023 Aug 3. PubMed

Ahmed F, Nowalk MP, Zimmerman RK, Bear T, Grijalva CG, Talbot HK, Florea A, Tartof SY, Gaglani M, Smith M, McLean HQ, King JP, Martin ET, Monto AS, Phillips CH, Wernli KJ, Flannery B, Chung JR, Uzicanin A. 在COVID-19大流行之前和期间,急性呼吸道疾病期间的出勤率, United States, 2018-2022. medRxiv 2023.

Kenigsberg TA, Goddard K, Hanson KE, Lewis N, Klein N, Irving SA, Naleway AL, Crane B, Kauffman TL, Xu S, Daley MF, Hurley LP, Kaiser R, Jackson LA, Jazwa A, Weintraub ES. mRNA - COVID-19双价增强剂和流感疫苗同时施用. Vaccine. 2023 Sep 7;41(39):5678-5682. doi: 10.1016/j.vaccine.2023.08.023. Epub 2023 Aug 19. PubMed

Tchesnokova V, Larson L, Basova I, Sledneva Y, Choudhury D, Solyanik T, Heng J, Bonilla TC, Pham S, Schartz EM, Madziwa LT, Holden E, Weissman SJ, Ralston JD, Sokurenko EV. 尽管抗生素处方减少,但耐环丙沙星大肠杆菌的社区流通增加. Commun Med (Lond). 2023 Aug 12;3(1):110. doi: 10.1038/s43856-023-00337-2. PubMed

Researchers in Vaccines & Infectious Disease

Lisa A. Jackson, MD, MPH

Senior Investigator
Lisa.A.Jackson@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director, Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Biostatistics Investigator
206-287-4257
Andrea.J.Cook@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Onchee Yu, MS

Principal Collaborative Biostatistician
206-287-2389
Onchee.Yu@kp.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Senior Collaborative Biostatistician
206-287-2557
Robert.D.Wellman@kp.org

Curriculum vitae (CV)

Clarissa Hsu, PhD

Associate Investigator
206-287-4276
Clarissa.W.Hsu@kp.org

Curriculum vitae (CV)

Brian D. Williamson, PhD

Assistant Biostatistics Investigator
206-287-2024
Brian.D.Williamson@kp.org

Curriculum vitae (CV)

Noorie Hyun, PhD

Assistant Biostatistics Investigator
Noorie.Hyun@kp.org

Curriculum vitae (CV)

Pamela A. Shaw, PhD, MS

Senior Biostatistics Investigator
Pamela.A.Shaw@kp.org

Curriculum vitae (CV)

Annie Piccorelli, PhD

Senior Collaborative Biostatistician
Annie.V.Piccorelli@kp.org

 

Affiliate researchers

Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center

Adjunct researchers

John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington

Elizabeth Lin, MD, MPH
凯撒基金会华盛顿家庭诊所健康计划;
利记官网 Washington Health Research Institute